AS guesses as to how Pfizer Groton will look in Jan 2013? Just an ex PFE trolling
"What is pdm? Process Development and Manufacturing?"
Pretty Dumb Managers. And "pretty" doesn't imply good looks either, but rather more along the lines of "very."
cant pin the whole mess on hts. More to do with the phiosophy and motivation behind it. That "numbers" approach you mentioned became the norm in every department. Yes, the idiots did want to see graphs that go up. And when that spreads to the clinic youve got real problems. If it wasnt for 'creative' statisticians we would never have got anything to the market. HTS may have started the decline, but the final nail in Pharmas coffin came when the rest of the departments joined in in the collective dishonesty. The jerks that were responsible may now be getting tossed out - but their legacy remains well intrenched. No, its not safe to stay. This industry is in palliative care - line your pockets and get out.
but that was the issue. The individuals behind HTS were behind it for one reason only. They were not scientists. They were ambitious and saw a way to progress their career. The idiots at the top (Steere and co) look for graphs that go up. The higher the number the better, right? And yes, all the drug companies copied Pfizer. HTS conferences were a laugh. Full of screening managers and individuals that called themselves assay developers (even though all they did was bring in commercial SPA and HTRF kits from amersham and the likes - Chris Williams for christ sake....) all strutting around claiming that their amps went up to 11. Pointless posters of shite data from FLIPR with Galpha16 coupled overexpressed receptors in rodent ovary cell lines - highly representitive of human pathology? - methinks not. 20 years of that twatology and what do we have to show for it. An ageing population with poorly controlled diseases - disorders still being treated with allopurinol, phenytoin, methotrexate, aspirin, warfarin - drugs at least 50 years old. Everyone involved in HTS should be thoroughly ashamed of themselves; not just because of the suffering that continues due to their self-obsessed intellectual impotence, but because their malignant 'more is better' philosophy bastardized the integrity of the industry (yes, it once had integrity) and resulted in the hundreds of thousands of sackings over the past 15 years. But there is light at the end of the tunnel - pharma is getting wise to the legion of imbeciles who based their career on the 'numbers' approach. We (novartis) finally flushed out of one of the original Pfizer HTS idiots. DB (Father Dougall). His stupidity ultimately destroyed pfizer but we caught it just in time. Zaragon Life Sciences my arse - sitting lonely in a room surfing the web more like. And Over-The-Hill (Father Ted) soon to follow. Perhaps its worth staying in this industry afterall.
I could never understand the rationale behind HTS where instead of reacting A with B and testing the purified product C you reacted A with B, B1, B2,.......Bx and tested the mixture C, C1 C2.....Cx.
If the mixture had some activity you still had to find the active component.
I thought at the time I was just thick but now it seems it was a case of the Emperor's clothes.
Or have I still got it wrong????
What is pdm? Process Development and Manufacturing?
please, dont be so obsessed with clown shoes. He wasn't the primary tumor. That originated in Sandwich and Groton HTS. That is what started the whole sorry industry decline. The twats who sold the idea that screening more, faster, meant more marketed medicines. Steere and co, all thick as shit, bought the idea, and knew that they could sell it to, and I quote, "the superficial market intellects". And every other company copied our mistakes. And so started a 20 year period of imbeciles being promoted to positions of influence based on false measures of productivity. Rolph, MacKenzie, clown shoes and co are mearly the repugnant offspring of that period of malignant stupidity. I suspect you hate them. But do you hate them as much as you hate yourself given that you made no attempt to stop them. Oh, that mortgage, oh that healthcare coverage. Let's not rock the boat until its sinking.
"I hear Jeff is planning to auction off part of his collection at Sotheby's. However, you need to secure a spot soon as I hear there are many others with a keen interest in them because they're now seen as a requirement if one wants to scale the Corporate Ladder to the very top. The Timwit and Mackay have already placed deposits on a seat."
I got my seat. I want the "sports edition" CLOWN SHOES, you know, the ones with cleates, with a little personal spit and shine from Jeff on that fine crafted leather, but still with a little corporate slaughter on the soles to admire and pick through.
Drug safety and pdm merger will save some dollars.
"Does anyone know where I can get a good deal on some CLOWN SHOES?"
I hear Jeff is planning to auction off part of his collection at Sotheby's. However, you need to secure a spot soon as I hear there are many others with a keen interest in them because they're now seen as a requirement if one wants to scale the Corporate Ladder to the very top. The Timwit and Mackay have already placed deposits on a seat.
Ian you and the other old farts are too old to understand what's required to get things going - perhaps you need guidance from the younger Steve Jobs.
Clinical trials are currently slated for outsourcing. Think of some CRO in Delaware, USA (for the non-yanks). Groton is about to implode - not much left there but dead drift wood washing up on the beaches of the Thames from the sound.
Sad to see Pfizer go down this way, but the asses at the top have made it into a legal pyramid scheme. I hope the SEC investigates these ass-clowns for getting large severance pay-outs while hurting the company, local economy, and share holders.
Does anyone know where I can get a good deal on some CLOWN SHOES?
How 'bout you, Ian?
Rod - your taking Pfizer the same way as Rangers - a 3rd division outfit.
Development in Groton? Those bozos who blew $800million+ on a compound that raised blood pressure when the backup compound didn't. Blame it on the bozos.
A PGRD chemist that generated 3 block busters is now an academic at Imperial, london. A chemist that did not compete a lab book is in charge of WW research. Simples!
I have to agree with the statements listed below. Development in Groton is in total disarray, clinical trials are routinely run in an incompetent way and fail miserably. And these jackasses are always trying to blame everybody else for their failures. Everything at Groton right now can be easily outsourced or consolidated at another site. Nobody is safe there.
"Bunch of whine--ass ex-scientists. Groton may shrink and will probably dump the wasted lab space. But as a business hub, it will keep working on supporting any drugs we bring in. The "R" part of the business may be shuffled off, but the development and marketing pieces will continue to flurish"
You are joking, aren't you? Pfizer may still have the reputation of a decent developer of drugs, but that reputation is tarnishing daily. The lawyers are exhausted from the number of fuck ups from the BoD and dodgy clinical trials, the sales force is spent, and any research companies with a desire to see the fruits of their efforts succeed are not going to want to have a massive blue albatross hung around their necks. All it will take is another major lawsuit and your share options will be worth less than the paper they are printed on.
You got it wrong, Groton isn't cool for science, isn't cool for development, isn't cool for management. The Pfizer model is to only be in cool places. NY, Kendall Sq, La Jolla. If your not based in cool place your stupid whatever your role, it's Pfizer law.
Bunch of whine--ass ex-scientists. Groton may shrink and will probably dump the wasted lab space. But as a business hub, it will keep working on supporting any drugs we bring in. The "R" part of the business may be shuffled off, but the development and marketing pieces will continue to flurish
2Q results out soon. Lipitor sales zip all. Operating profit down 40+%. Even Viagra is off patent soon. Time for another takeover.
Groton is (burnt badly) TOAST.
Pfizer's new research model is to outsource early discovery research to academic labs. The evidence is found in the new Centers for Therapeutic Innovation. Google is your friend.
Sorry if you own a home in the area. It's a money pit, usually relegated to a boat: a hole in the water in which to pour money.
i concur with the last message.
Closing groton, closing alewife and renting EXPENSIVE space in Kendal square area of Cambridge.
Groton is toast.
When the announcement came out about the move of the Neuroscience and CVMD units moving to Cambridge, MA (Feb 2011), most people gave the Groton site five years before it gets closed. And at this point, I am not seeing any change in that prediction. Half the site is up for sale or rent, and there are no takers. Scientists who were laid off, are leaving the state as soon as the can for greener pastures. So I say by Feb 2016 Groton will be closed and the Cambridge site will be gone. Pfizer becomes a virtual lab company for R&D.
July 5 looks about the same as July 3
2013 is two rearrangements of Research and at least one layoff. How in the world am I suppose to know what Groton will look like. I just hope I know what the structure is on July 5.
Perhaps judging by the banks fines recently in the UK/US & GSK's recent payout that the model of governments supporting things is coming to an end.
Without products that are effective & the market that can support them then the big Pharma model is finished.
Sad to see Pharmas now consigned to the ranks of doggy banking speculation, it was not the career I chose in the 80's.
Glad to be out of it.
Remember the good times, break through products & an industry with integrity.
hey rod and ian,
keep pushing the koolaid. i wish i was there with you to drink it and toast to your well-deserved termination. you guys are the best... C and D players in the industry... ruining a once great company. you should hate one another for not bringing the best medicines to market. your leadership is focused on short-term profits instead of great medicines to help patients and build long-term growth to sustain further treatments for patients and stockholder value. pfizer has had so much talent pass through it and nothing to show for it. you two are a bunch of bozos that need specific instructions on how to tear open a bag to complete your EXIT from pfizer.
Pfizer is a financial powerhouse. It is unstoppable. One of the smartest business moves to align itself with big banks. Remember big banks control the politians. Pfizer is protecting itself!!! Long Live Ian Read!!!!!!!
You are right. Pfizer's many acquisitions has made the banks very rich through fees. Maybe this is why Kindler got a position on the NY Federal Reserve. I suppose this is what its about. It is certainly not about shareholders. The hundreds of billions spent to buy these companies did not result in hundreds of billions in shareholder value (mostly, the value was flushed down the toilet). The business model is very flawed, but they keep doing it. Pfizer is of, by and for the banks.
Come on guys get real. Pfizers at it again - sell off units to raise some cash, buy another big pharma in trouble, asset strip your lives away. It the Pfizer buisness model. Makes the bankers very rich.
I would think that getting rid of TH is a bad omen. No site lead, no site.
Make sure you sharpen that resume and work those connections Dr. Superior.
PFE will be stronger than ever in 2013. Approvals are at an all time high. All the worthless employees have been ATSed and only the best and brightest minds remain. Productivity is at an all time high.
The stock will only continue to rise under the leadership of IR.
To prove my point that PFE is turning in the right direction: they got rid of TH!
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