whats up at Pacbio. MH seems to be cooksure by taking salary cut to
$1. Does he know something we don't or just keep floging a dying horse. Will the promised 15 min human genome sequencing in 2014 be materialised?

With only one new instrument ordered in Q2 and all outstanding orders filled, they should have the manpower to send multiple service techs to each service call.

what is the mean time to repair on these beasts now....still approximately one week?

Hugh Martin has re-appeared:
http://www.xeralux.com/about/management.html

My point was that requiring hype in order to get properly funded is not working for sequencing. The model has been distorted. Even if a US concern aquires IP from overseas, they still need to properly manage domestic talent. Fairy tales are not the best way to inspire smart people.

"That's right, the US ones, maxam-Gilbert, ligation (Lynx and SOLiD), Helios, pacbio - all tanked."

No Way !

That's right, the US ones, maxam-Gilbert, ligation (Lynx and SOLiD), Helios, pacbio - all tanked.

Actually the top four sequencing technologies in the world were in invented and initially developed in Europe. The Uk and Sweden, they were later commercialized from the US after acquisitions.

Certainly this sector has big challenges but greed and stupidity are not the whole story. The lottery/herd mentality that fuels what direction much capital takes has paid off for internet based enterprises but not so much sequencing. The previous technology bust cleared the way for the US to lead the world in technology design (device/software). Maybe we have to have these mini “sequencing busts” to advance development according to how we do things in the US? Do you know for sure that PacBio would never succeed? Maybe we need to stop requiring hype in order to get properly funded so that cutting edge ideas can flourish from our highly productive US talent base?

Didn't see Hunka was the new boss, well this means a more solid instrument and some better science but Mike is not best known for cost cutting, however, he knows how to turn a tech into a workhorse... Interesting. I still think this will be a POS, simply because the market is S.

This company is a poster child for this fake genomic bubble that will never come within this generation. We don't give a damn about how fast and how cheap you do raw sequencing. Its meaningless and it's certainly scary when you do it with a worthless service intense behemoth. What a joke. We all knew this was shit, only a few said it and VCs wanted to believe it because THEY ARE GREEDY. I'm so happy you got screwed. There is no one trick poney in biotech, it's mostly me too companies with little innovation. Genomics is a sad sad story of unfilled promises and dumb scientists are too lame too, so naive.

there's no doubt this company will fail, but that's not a good thing for the industry. So many VC's pumped money into this company, it will take quite a bit to get big investor money back into this sector.

Get a grip people, CEO's don't change squat in our field, ya maybe Pac Bio will suck a bit less for 2 quarters and he will stroke himself and then he will bleed this mofo to madness. I mean wake up, this company should never have existed.

The final throws of a failing company. MH is capable but the challenge is insurmountable. PacBio will be gone in less than 10 months, bank on it.

If anything having MH as CEO strengthens PacBio. HM is not a scientist. MH is.

http://www.arkancide.com/psychopathy.htm

Looking at those lawsuits, you will know why. HM may be go to jail?

MH named, HM steps down. Anyone know why?

http://finance.yahoo.com/news/Pacific-Biosciences-Names-bw-232540545.htm...

Pacbio has nothing left to sell. Buh-bye then.

With a 15% error rate and no solution in the horizon, what do you expect?
Great way to get into 3rd generation!

No. No Hope, no Jobs, No Cash.

they just interviewed me, do you think this company still has some hope?

"Now that the burn rate is lower and the company is more stable than before it will stay for a longer time"

Stay for 1.5 years instead of 1? More layoffs are a comin'!

Very interesting comments from lots of outsiders. Why not some comments from insiders? How is the morale? I heard that they are actually not so bad from a friend of mine. Now that the burn rate is lower and the company is more stable than before it will stay for a longer time. It's long read capability will make it a good match with Illumina's short read high-throughput system. Time will tell.

test

wow...going the way of Helicos. Six months, stick a fork in 'em...

"PB under investigation:
http://finance.yahoo.com/news/Zeldes-Haeggquist-LLP-bw-3589388603.html?x=0"

To quote Mr. Simpson, "Doh!"

PB under investigation:
http://finance.yahoo.com/news/Zeldes-Haeggquist-LLP-bw-3589388603.html?x=0

So with 30% of the work force cut when will the 15 minute human genome be sequenced?

Does this mean it won't be until December of this year or will it take just a little bit longer like 2050?

Well, I would like to hear as well but understand if no one does. People still there, and those just departed, are still hoping for an equity payout someday. If still inside, posting negatively won't add at all toward that goal, and positively could (perhaps) cause SEC type issues. If gone already, you are free to post whatever, but readers would need to question the veracity due to questions of motive. But don't let me disuade you, post away, what is really happening?

I'd like to know how it's going internally there. There has to be a huge morale issue right about now. They've been told there are back orders for over a year, yet none of these are getting filled.

15% error rate? PacBio used to be very vague about their error rates. They always either vaguely aswered error rates questions or avoided to answer it at various Genome conferences. Therefore, I was skeptical about them. Now thruth is comming out. With a 15% error rate the technology is basically a crap. It is useless for sequencing without combining with other technologies. Then, why pay for their instruments when you need another technology.

PacBio : some great science, but you built the wrong thing.

Anyone need a really experienced image processing/machine vision/machine learning guy? I'm also good with dogs.

R&D always gets killed first. Companies that don't see a future don't invest in it.

I mean it will be about 30%, it starts now.

~30%

I heard 120 or so. Isn't that more like 30%

You dont need R & D to spell Pacific Biosciences!

About 20%, the cut is going to sting.

RIP everyone who gets cut tomorrow.

"When do the layoffs start?"

What layoffs? Is this concrete or just speculation?

When do the layoffs start?

I take it that's a no?

Is PacBio a good place to work? LOL the American Scam is over old dude. Who is the big investor in this company? Tell the truth, anyone...

Is Pac Bio a good place to work?

"PacBio was downgraded by JPMorgan."
Todays news may change the meaning of downgrade, so i don't trust "restyling sito internet":http://www.yousite.it/restyling-siti-web.html

I want to work for PacBio, I hope they lay you off and hire me!! =)

wonder if HM still has his lobster cookoffs for the company - everyone gets their own lobster? maybe (red) herring now?

bite bite bite - i called it, i called it, i called it - covering short today. thank you folks for the smoke n mirrors!