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An international team of scientists has achieved a breakthrough by finding the genetic cause of a very rare and aggressive type of ovarian cancer that most often strikes girls and young women.The study, led by Translational Genomics Research Institute (TGen) a non-profit organization based in Phoenix, AZ, is published in the journal Nature Genetics.
According to a World Health Organization report released today, around 1 in 8 of total global deaths - 7 million deaths annually - are as a result of exposure to air pollution.The new data challenges previous information on air pollution. The figure of 7 million more than doubles the previous estimate of annual air pollution-caused deaths, making air pollution now the world's largest single environmental health risk."The risks from air pollution are now far greater than previously thought or understood, particularly for heart disease and strokes," says Dr.
Multiple sclerosis is characterized by disrupted communication between the brain and the body, resulting in symptoms ranging from blurred vision to muscle weakness and pain. There is no cure for the condition, and therapies have proven difficult, as many have serious side effects. But now, relief may come in the form of a medical marijuana pill.This is according to a new guideline released from the American Academy of Neurology and published in its journal Neurology.The guideline investigated complementary or alternative medicine therapies (CAM) for multiple sclerosis (MS).
A team of chemists from the UK has made a remarkable discovery about the structure of bone and shown that much of the mineral from which it is made comprises a viscous 'goo-like' fluid that is trapped between the crystals that form bone. They say their findings reveal new insights into bone diseases like osteoporosis.The goo-like fluid allows movement or slipperiness between the calcium phosphate nano-crystals so they do not shatter under pressure.
Thousands of young people at risk of 'slipping through the net' due to adults' lack of mental health awareness, UK
More than half of adults lack the confidence to approach a child, or a parent of a child that they suspect to have a mental health problem, in case they are mistaken, a new survey launched today reveals. The survey comes as a new website - MindEd - funded by the Department of Health launches. It will provide adults with the knowledge and skills to help address this lack of mental health awareness.
Researchers at the University of Freiburg have found switches that colorectal cancer cells use to migrate away from the primary tumor site and to invade neighboring tissue. This migration is the first step in metastasis, the process by which the cancer forms secondary tumors in other organs. Prof. Dr. Andreas Hecht and his research group at the Institute of Molecular Medicine of the University of Freiburg published their findings in the journal Proceedings of the National Academy of Sciences (PNAS).
Non-invasive gene expression profile test shown to identify sentinel lymph node negative melanoma patients at high risk of metastasis
Castle Biosciences Inc. has announced study results showing its gene expression profile (GEP) test (DecisionDx-Melanoma) can identify primary cutaneous (skin) melanoma tumors that are likely to metastasize in patients who had a negative sentinel lymph node biopsy. The data are being presented at the Latest in Dermatology Research Symposium session of the 72nd Annual Meeting of the American Academy of Dermatology. The DecisionDx-Melanoma test completed validation in 2013 and is widely used to determine metastatic risk in Stage I and II melanoma patients.
Celgene Corporation has announced that the U.S. Food and Drug Administration (FDA) has approved OTEZLA® (apremilast), the Company's oral, selective inhibitor of phosphodiesterase 4 (PDE4), for the treatment of adult patients with active psoriatic arthritis. A chronic disorder, psoriatic arthritis is characterized by pain, stiffness, swelling and tenderness of the joints, inflammation of specific ligaments and tendons, and a decrease in physical functioning. OTEZLA is the only FDA-approved oral treatment for psoriatic arthritis.
FDA approves Xolair® (omalizumab) for people with Chronic Idiopathic Urticaria (CIU), a form of chronic hives
Novartis has announced that the US Food and Drug Administration (FDA) approved Xolair® (omalizumab) for the treatment of chronic idiopathic urticaria (CIU), a form of chronic hives. The new use is for patients 12 years of age and older who remain symptomatic despite treatment with H1-antihistamine therapy. Xolair is not used to treat other forms of urticaria (hives) and is not for use in children less than 12 years of age. Xolair is jointly developed by Genentech and Novartis Pharma AG and is co-promoted by Novartis Pharmaceuticals Corporation with Genentech in the United States.
The National Institute of Pediatrics (INP) in Mexico, conducted a study on genetic markers to identify children with acute leukemia, who may suffer side effects from the medications used to treat this type of cancer.Genetic markers studies are used to identify which patients are susceptible to side effects of a drug used in chemotherapy called methotrexate, which can cause mucositis or an inflammation of the mucosa and even death.Dr.
Research published today (24 March 2014) provides critical new insight on the harmful links between smoking tobacco and developing tuberculosis (TB). Regular tobacco smoking doubles the risk that people who have been successfully treated for TB will develop TB again - a condition known as "recurrent" TB. The study is the most robust ever conducted into how smoking tobacco increases the risk of recurrent TB. It appears in the April issue of the International Journal of Tuberculosis and Lung Disease.
Young children who sleep less eat more, which can lead to obesity and related health problems later in life, reports a new study by UCL researchers.The study found that 16 month-old children who slept for less than 10 hours each day consumed on average 105kcal more per day than children who slept for more than 13 hours. This is an increase of around 10% from 982kcal to 1087kcal.
Cancer Research UK's Drug Development Office (DDO) has launched a trial of a vaccine to treat some forms of cancer caused by a common virus known as the Epstein Barr Virus (EBV).The trial is being presented today (Tuesday 25 March) at a conference to mark 50 years since Cancer Research UK first discovered the link between the EBV virus and cancer*.The Epstein-Barr virus (EBV) infects most people in the UK, although it rarely causes medical problems.
Brief behavioral and mental health programs for children can be effectively provided within pediatric practices as an alternative to being referred to a community specialist, University of Pittsburgh Schools of the Health Sciences researchers found in a National Institutes of Health-funded randomized trial.
Artificial booster makes immune system dramatically more effective in fighting pneumonia and meningitis
Researchers at the University of Leicester have produced an artificial version of a naturally occurring protein, properdin, which has been found to successfully combat bacterial pneumonia and meningitis when tested in mice.In the new study, published today (24 March) in the online early edition of the journal Proceedings of the National Academy of Sciences (PNAS), the researchers have shown that a booster of the innate immune defence has a profound and immediate effect on the body's ability to clear infections, even when the bacteria have reached the bloodstream.
Hotel guests can be gently persuaded to reduce the number of towels they use each day, psychology researchers at the University of Luxembourg have found. With fewer towels to wash, this reduces the waste of water, energy and detergent. This is good news for the environment and it cuts costs, so enabling hotels to reduce prices.Two hotels in Swiss and Austrian ski resorts helped with an experiment in early 2013. Three different signs were placed separately in different bathrooms, all of which gently reminded guests of the environmental impact of towel use.
We all feel better after a good night's sleep, but increasingly, evidence is suggesting that not getting enough good-quality sleep could increase our risk of type 2 diabetes, obesity and other metabolic disorders.A new study, published in The Lancet Diabetes & Endocrinology, suggests that both the prevention and treatment of these disorders may benefit from addressing poor sleep.Metabolic health in humans is dependent on a mixture of behavioral factors and genetic predisposition.
A fatty fold of tissue within the abdomen that is a rich source of stem cells can help heal diseased kidneys when fused to the organs, according to a study conducted in rats. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN) suggest that stem cells from within a chronic kidney disease patient's own abdomen could be used to preserve and possibly improve kidney function.Although adult stem cells have shown promise in treating experimental acute kidney diseases, it's unknown whether they might also alleviate chronic kidney diseases.
During the 43rd Annual Meeting & Exhibition of the American Association for Dental Research, held in conjunction with the 38th Annual Meeting of the Canadian Association for Dental Research, a symposium titled "Water Fluoridation: Safety Efficacy and Value in Oral Health Care" took place. This symposium was chaired by Stephen H. Abrams, Cliffcrest Dental Office, Toronto, Ontario, Canada.Community water fluoridation (CWF) and other fluoride modalities historically have been and remains the cornerstone for the prevention and control of dental caries.