A visit to the dentist could one day require a detailed look at how genes in a patient's body are being switched on or off, as well as examining their pearly whites, according to researchers at the University of Adelaide.In a new paper published in the Australian Dental Journal, researchers from the University of Adelaide's School of Dentistry have written about the current and future use of the field of epigenetics as it relates to oral health.
Thirty percent of adults with Attention Deficit Disorder or Attention Deficit Hyperactivity Disorder (ADD/ADHD) report they were physically abused before they turned 18. This compares to seven per cent of those without ADD/ADHD who were physically abused before 18. The results were in a study published in this week's online Journal of Aggression, Maltreatment, and Trauma.
Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease. The results are published in the journal Nature Communications.
Approximately one in six veterans struggles with substance abuse, and 20 percent show signs of mental health issues or cognitive impairments, previous research has shown. These risk factors, combined with a lack of resources, could be contributing to an increase of veterans entering the criminal justice system, according to a report by the Center for Mental Health Services. Now, University of Missouri researchers have investigated ways social workers can address veterans' needs and keep them out of jail.
Millions of high school and college algebra students are united in a shared agony over solving for x and y, and for those to whom the answers don't come easily, it gets worse: most preschoolers and kindergarteners can do some algebra before even entering a math class.
Understanding more about how the different types of cells in breast tissue develop improves our knowledge of breast cancer. TAZ represents a potential new target for drug therapies to treat aggressive types of breast cancer.In cancer, normal cells can become unpredictable or aggressive and thus difficult to treat with anti-cancer drugs. This is especially true in breast cancer. By identifying the genes responsible for this change in cells from breast tissue, researchers hope to identify a way to stop or reverse it.
Ignaz Semmelweiss made one of the most important contributions to modern medicine when he instituted hand washing in an obstetric clinic in Austria in 1847, decreasing mortality there from more than ten percent to two percent. Unfortunately, infections can still occur in pregnancy and during delivery and can have associated mortality rates of up to 30 to 50 percent if not treated quickly and properly.
Doctors' unconscious biases favor whites but do not affect high blood pressure treatment for their minority patients, according to a University of Colorado Boulder study, even though a previous study by the same research group found that doctors' biases are reflected in lower ratings by African-American patients.The new research, led by Irene Blair, an associate professor in CU-Boulder's Department of Psychology and Neuroscience, is published in the Journal of General Internal Medicine.
A study conducted by local high school students and faculty from the Department of Computer and Information Science in the School of Science at Indiana University-Purdue University Indianapolis reveals new information about the motor circuits of the brain that may one day help those developing therapies to treat conditions such as stroke, schizophrenia, spinal cord injury or Alzheimer's disease."MRI and CAT scans of the human brain can tell us many things about the structure of this most complicated of organs, formed of trillions of neurons and the synapses via which they communicate.
Colchicine, a drug that's used to treat gout, has the beneficial side effect of lowering the risk of heart attack in patients taking it. Conversely, taxol, a drug for treating cancer, has the opposite effect; raising the risk of heart failure.What both these drugs have in common is that they act on microtubules - a network of fibers inside heart cells that provide internal structural support.
In a rat model of myocardial infarction, transplanted human umbilical cord blood cells improved heart function
When human umbilical cord blood cells were transplanted into rats that had undergone a simulated myocardial infarction (MI), researchers investigating the long term effects of the transplantation found that left ventricular (LV) heart function in the treated rats was improved over those that did not get the stem cells. The animals were maintained without immunosuppressive therapy.The study will be published in a future issue of Cell Transplantation but is currently freely available on-line as an unedited early e-pub.
Our intestines harbour an astronomical number of bacteria, around 100 times the number of cells in our body, known as the gut microbiota. These bacteria belong to thousands of species that co-exist, interact with each other and are key to our health. While it is clear that species imbalances may result in disease, it is unclear at what pace does each species in the gut evolves, a process that contributes to the chance of a particular innocuous species becoming harmful to the host.
It's by now well established that obesity is a major risk factor for diabetes. But what exactly is it about extra body fat that leads to insulin resistance and blood glucose elevation, the hallmarks of diabetes?Over the past several years, Beth Israel Deaconess Medical Center (BIDMC) endocrinologist Barbara Kahn, MD, has developed a large body of research suggesting that a molecule called retinol binding protein 4 (RBP4) plays a key role in the process.
Black boys as young as 10 may not be viewed in the same light of childhood innocence as their white peers, but are instead more likely to be mistaken as older, be perceived as guilty and face police violence if accused of a crime, according to new research published by the American Psychological Association."Children in most societies are considered to be in a distinct group with characteristics such as innocence and the need for protection.
Classroom programs designed to improve elementary school students' social and emotional skills can also increase reading and math achievement, even if academic improvement is not a direct goal of the skills building, according to a study to be published this month in American Educational Research Journal (AERJ). The benefit holds true for students across a range of socio-economic backgrounds. In the study, "Efficacy of the Responsive Classroom Approach: Results from a Three Year, Longitudinal Randomized Controlled Trial," researchers Sara Rimm-Kaufman (University of Virginia), Ross A.
A model of care developed by the Department of Psychiatry at LSU Health Sciences Center New Orleans School of Medicine to provide mental health services after the Deepwater Horizon Gulf Oil Spill reduced both mental health and general medical symptoms. The novel approach embedded psychiatrists, psychologists, social workers and telemedicine resources into primary care clinics in the most affected areas. This new model can be used in communities at risk for disasters and rural communities with limited mental health resources.
VERBAL and physical aggression towards health and social care staff is on the increase. The NHS has reported a rise of 5.8 per cent in reported assaults - up to 63,199 in 2012/13. Now a University of Huddersfield lecturer has called for a programme of research to establish the best methods for dealing with the problem.Various techniques known as "de-escalation" have evolved in order to calm threatening situations.
Patients are more likely to raise a health problem with a doctor they've seen over time and have built-up a relationship with, new research has revealed. The insight comes as an increasing number of patients struggle to see the same GP.Researchers from the University of Bristol will shared their findings with health practitioners and researchers at the recent South West Society for Academic Primary Care (SW SAPC) meeting.
An international group led by Vanderbilt University researchers has found cannabinoid receptors, through which marijuana exerts its effects, in a key emotional hub in the brain involved in regulating anxiety and the flight-or-fight response.This is the first time cannabinoid receptors have been identified in the central nucleus of the amygdala in a mouse model, they report in the current issue of the journal Neuron.The discovery may help explain why marijuana users say they take the drug mainly to reduce anxiety, said Sachin Patel, M.D., Ph.D.
A simple questionnaire that rates breathing difficulties on a scale of 0 to 3 predicts survival in chronic graft-vs.-host disease, according to a study published in the March issue of Biology of Blood and Marrow Transplantation.And although a poor score means a higher risk of death, asking a simple question that can spot lung involvement early means that patients can begin treatments to reduce or manage symptoms, said senior author Stephanie Lee, M.D., M.P.H.